Mood disorders can prove hard if not treated properly. There are certain drugs known as anti-depressants that can work effectively to alleviate conditions such as anxiety and depression. One of such drugs is amitriptyline.

 Amitriptyline is a medicine that is used for treating depression and anxiety. In some cases, doctors also prescribe it for the ADHD patients.
It is an anti-depression drug not to be taken without a prescription.


Amitriptyline is prescribed to treat mood disorders such as depression and anxiety. However, in low doses, this medicine can work as a painkiller for migraine and other generic aches.
For treating depression, its dose increases the serotonin level in the brain.

Serotonin is a neurotransmitter that affects sleep and overall energy of the body. It helps reduce the pain in the body. As a painkiller, it is used in conditions such as arthritis, fibromyalgia, neuralgia or migraine.

The pain therapy may require a minimum of six weeks to start its effect.

How to take it?

Amitriptyline comes both in tablet and syrup form. The medicine should be taken a couple of hours before bedtime. You may feel sleepy after taking the medicine because it works as a muscle relaxant. However, if you don’t feel sleepy after taking it, change the time of taking it.

Taking the medicine till evening can help you go into proper sleep at the right time.


Amitriptyline dosage depends on the condition.

For Depression

The medicine dosage starts with 25-50 mg per day, orally at bedtime.
The doctor will adjust the dose every 5-7 days by increasing 25 mg.
The maximum dose for depression can be 300 mg per day (divided doses)

For Migraine

The regular adult dosage for migraine is 10-25 mg per day orally before bedtime.
Maximum daily dose for migraine can go up to 400 mg.

For neuralgia

The usual adult dosage for back pain is 65-100 mg before bedtime orally.

Side Effects

Amitriptyline can cause side effects such as

  • Dizziness
  • Constipation
  • Dry Mouth
  • Blurred Vision
  • Urine flow issues

Immediately see a doctor if you see any side effects such as:

  • Bruising under the skin
  • Stool that is tar-like
  • Lowering of libido
  • Muscle spasms
  • Stomach pain that doesn’t go away.

A very serious side effect to this medicine is Neuroleptic Malignant syndrome which is characterized by irregular fast heartbeat and stiffness of muscles. Although it is rare, it can happen to people who are taking this medicine.

Allergic reactions to the medicine can include:

  • Swelling of the face
  • Skin rash
  • Swelling of the tongue

For any such side effect, seek immediate medical help.


Give your doctor a complete history of mood disorders whenever you seek medical help for a psychiatric problem. This drug is prescribed for mood disorders, but it can worsen many neurotic conditions such as extreme bipolar disease.
Tell your doctor about the history of a liver or kidney problem to avoid dangerous side effects. Amitriptyline affects the heart rate, so if you have any cardiac issue, inform your doctor before he prescribes it to you.